新药长毒试验动物血液生化测定规范化研究系列之六--SPF级Wistar大鼠血液生化参考值的建立
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R-331


Establishment of the Range of Normal Values of Blood Biochemical Measurements in SPF Wistar Rats
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    摘要:

    目的 建立新药慢性毒性试验Wistar大鼠血液生化参考值。方法采用全自动生化测定仪对不同年龄、不同性别SPF级Wistar大鼠的血液生化值进行了测定。结果取得不同年龄、性别Wistar大鼠血液生化值平均值及参考值范围。多数生化指标受年龄及性别因素影响。其中,不同性别TBil、ALP、TG,不同年龄ALP、CK、TG、CHO变化最具规律性。结论在新药慢性毒性试验中,雌雄Wistar大鼠血液生化指标不宜合并统计,在比对参考值时应考虑到性别与年龄的因素。

    Abstract:

    Objective To provide normal range and mean value of blood biochemical parameters in SPF Wistar rats to serve long-term toxicity test as reference baselines. Methods Blood samples were taken from SPF Wistar rats in different age and sex. By using an automatic chemistry analyzer, a variety of blood biochemical parameters were measured. Results Normal range and mean values of all parameters were obtained. Most biochemical measurements were influenced by age and sex of the rats. The variations of TBil, ALP, TG in rats of different sex and ALP, CK, TG, CHO in rats in different age showed an apparent regularity. Conclusion It is not proper to combine the biochemical data obtained from female and male rats together for statistical analysis in long-term toxicity test. When data are compared with normal values and ranges, attention should be paid to the influence of are and sex of Wistar rats on variation of blood biochemical values.

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齐云,蔡润兰,王敏,宋杨,刘彬,李永超,赵德明.新药长毒试验动物血液生化测定规范化研究系列之六--SPF级Wistar大鼠血液生化参考值的建立[J].中国比较医学杂志,2006,(4):197~200.

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  • 收稿日期:2005-12-20
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