Objective Two polycystic-like ovary syndrome models in rats induced by testosterone or HCG were compared.Methods In the model 1,Female Sprague-Dawley rats at age of 9 days were given subcutaneous injection of testosterone propionate.In the model 2,Female Sprague-Dawley rats at age of 24 days were given subcutaneous implant of levonorgestrel.3 days later HCG was subcutaneously injected to these rats for 9 days.Then the ovulation,morphology of ovary,blood serum levels of testosterone(T),estradiol(E-2),follicular stimulating hormone(FSH),luteinzing hormone(LH),fasting plasma glucose(FPG),fasting insulin(FINS) in the two models were assyed.Results Rats of both two models showed polycystic ovary-like syndrome manifestation.But the ovary of rats in model 1 was smaller than that of controls,and bigger in model 2.Serum levels of T,FPG,FINS increased in two models.Serum levels of E-2 increased,FSH and LH decreased in model 1.Serum levels of FSH and E-2 decreased,LH increased in model 2.Conclusion The two polycystic ovary-like syndrome rat models manifested with PCO,hypertestosteronemia and hyperinsulinemia.Those rats showed similar changes in human PCOS,and can be used as model animals for certain rat experimental research.