小檗碱对2型糖尿病中国地鼠的治疗作用
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R583.1


Therapeutic Effects of Berberine on Type 2 Diabetic Chinese Hamsters
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    摘要:

    目的研究小檗碱治疗2型糖尿病的疗效。方法采用高能量、高脂饮食喂养,结合小剂量链脲佐菌素(STZ)腹腔注射的方法,建立中国地鼠2型糖尿病模型,随机分成9组,分别用生理盐水、低剂量(50 mg/kg)、中剂量(150 mg/kg)、高剂量(300 mg/kg)小檗碱及二甲双胍灌胃给药的方法干预性治疗,观察、比较小檗碱的治疗效果。结果小檗碱有明显降糖降脂和增强胰岛素敏感性的作用,其作用有时间效应性和剂量效应性,其降糖效果与二甲双胍相似,但作用较和缓。结论高能量高脂饮食结合小剂量链脲佐菌素腹腔注射建立2型糖尿病地鼠模型的方法,是目前制备2型糖尿病动物模型的较好方法。小檗碱有明显降低2型糖尿病中国地鼠血糖血脂、改善糖耐量、增强胰岛素敏感性的作用。

    Abstract:

    Objective To investigate the therapeutic effects of berberine on type 2 diabetic Chinese hamsters.Methods To establish a type 2 diabetic Chinese hamster model by injection of low-dose STZ intraperitoneally based on high fat and energy diet feeding.The animals were randomly divided into 9 groups,and each group was fed with physiological saline,low dose(50 mg/kg) of Berberine,moderate dose (150 mg/kg) of Berberine,high dose(300 mg/kg) of Berberine,and metformin to treat the type 2 diabetic Chinese hamsters.The curative effect of Berberine was observed and compared.Results Berberine showed obvious glucose-decreasing and lipid-decreasing effect,which had some effect related to its time and dose,and there were the same glucose-decreasing effect as metformin group and mild pharmacological action after treatment in moderate dose Berberine group.Berberine also could enhance the sensitivity to insulin.Conclusion Low-dose STZ injected intraperitoneally combined with high fat and energy diet is an excellent method to induce type 2 diabetes mellitus in Chinese hamsters.Berberine has significant decreasing effect on blood glucose and lipid level,improves is glucose tolerance and enhances the sensitivity to insulin in type 2 diabetic Chinese hamsters.

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李国生,刘栩晗,朱华,黄澜,刘亚莉,马春梅,秦川.小檗碱对2型糖尿病中国地鼠的治疗作用[J].中国比较医学杂志,2007,(10):559~562,567.

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  • 最后修改日期:2007-05-09
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