Objective To study the defend function of lyophilized bovine colostrums on alcohol liver injury in mice.Methods Objective Lyophilized Bovine Colostrums(350 mg/kg) 3 d.The alcohol model group also used 50% alcohol(12 mL/kg) together.The control group only used distilled water.The experiment tested biochemistry and alcohol liver injury in adipose.Results The Lyophilized Bovine Colostrums group and alcohol model group GSH,HDL-C increased significant and deceased The content of MDA,Its protect effect was also proved by liver patholgical changes in total score.Conclusion Lyophilized Bovine Colostrums had protectived effect on alcohol liver injury.