Toxicity pathology is the footstone of medicine preclinical safety evaluation. In practice, many problems were exist in pathological examination such as criterion were discordance, operating procedure was nonstandard and labanimal pathology study was unsubstantially, which severely threaten the running and effect of GLP. Therefore, toxicity pathology laboratory should execute the standardization of examination and promote laboratory certification and accreditation. It also was very important that strengthening research of comparative histology and comparative pathology in labanimal and building toxicity pathology database. All of this was to fundamentally accelerate the level of medicine safety evaluation.