Objective To elucidate the etiological factors inducing population urinary stone disease in a Beagle dog farm, and to set up an effective treatment and prevention of this disease. Method In this study clinical and pathological examinations were carried out, and to make diagnosis, composition of the urinary stones and feed were analyzed. Retrospective study was made and successful treatment was achieved. Result It was found that the etiological factor leading to the urinary stone disease was meat powder included in the feed for the animals. The urinary stones were composed of salt of urid acid. By alkalinizing the urine, degrading the urate in the blood and removing it, all Beagle dogs in that Beagle dog farm were effectively cured. Conclusion The meat powder for animals was found to be the only etiological factor and the degenerative nephritis owing to salt of uric acid caused urinary lithiasis, which has well been cured at the beginning and intermediate stage of the disease.