Objective To establish of a favorable rabbit model simulating the coronary radial artery bypass grafting. Method 50 New Zealand rabbits were used in this study. The femoral artery was end-to-side anastomosed with the common carotid artery. Meanwhile, to ligate the carotid artery between two anastomotic stomas. Next, take these integral artery grafts at 1 day, 3 days, 7 days, 14 days and 56 days after operation, respectively. Samples were taken for histopathological analysis. The sections were stained by HE and stained for elastic fibers, to measure the width of intima (WI) of the artery bridge and to calculate the index of intima/(intima+tunica media) (I/IMR) with a computer image analysis software, and to observe the change of the vascular endothelial cells by scanning electron microscopy. Result No death occurred during the operation and perioperationperiod in the 50 rabbits. The total patency rate of the artery bridges was 86%. The morphological examination revealed that the intima began to thickening in these smooth artery bridges at 7 days after transplantation and to be significant after 56 days. Conclusion This method is able to build up a favorable rabbit model of radial artery bridge in coronary artery bypass grafting.