大鼠慢性萎缩性胃炎模型的建立
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R573.32


Model Establishment of Chronic Atrophic Gastritis in Rat
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    摘要:

    目的建立大鼠慢性萎缩性胃炎(CAG)模型。方法饮用及灌胃给予20 mmol/L去氧胆酸钠和30%、60%乙醇13周。检测大鼠胃粘膜组织病理变化及生化指标。结果模型组大鼠胃窦粘膜的炎症指数明显增加,胃窦固有腺厚度和面积明显缩小;游离酸和总酸浓度明显降低,游离粘液量和胃蛋白酶活性明显升高,血清胃泌素及丙二醛含量明显升高,白细胞介素-2及超氧化物歧化酶活性明显降低。结论成功建立了CAG动物模型,为慢性萎缩胃炎疾病的研究提供了一种理想的动物模型。

    Abstract:

    Objective To establish a model of chronic atrophic gastritis in rat. Methods 20 mmol/L sodium deoxycholate and 30% ,60% alcohol were given in combinatin to rats to establish CAG model for 13 weeks. Pathologic changes of the gastric mucosa were observed by microscope, biochemical indexes were measured with instruments. Results Inflammatory index of gastric mucosa in CAG rats was significant increase, the thickness and area of inherent gland shrunk significantly ; the concentration of free acid and total acid were significant decrease, mucin contents and pepsase activity were significant higher, serum gastrin and malondialdedyeds contents enhanced significantly, interleukin-2 and superoxide dismutase activity decreased significantly. Conclusion Succeeded in establishment of an animal model of CAG, and provided an ideal animal model for the study of chronic atrophic gastritis.

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翦林宏,彭志辉,陈立峰,郑兵.大鼠慢性萎缩性胃炎模型的建立[J].中国比较医学杂志,2007,(3):161~163,I0001.

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  • 最后修改日期:2006-04-26
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