四种消毒剂对小鼠肝炎病毒MHV-A59的杀灭效果
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R33

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上海市科委资助项目


Evaluation of Inactivation Efficacy of Four Disinfectants against Mouse Hepatitis Virus
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    摘要:

    目的研究过氧乙酸等4种常规消毒剂对小鼠肝炎病毒MHV.A59的杀灭效果。方法按照2002版《消毒技术规范》中规定的试验方法进行中和剂鉴定试验以及病毒灭活试验。结果与病毒作用5min和10min后,3%的过氧乙酸、250mg/L的碘伏、含有效氯25mg/L的复方二氯异氰尿酸钠对MHV.A59的杀灭对数值均≥4,具备杀灭作用,而新洁尔灭的杀灭对数值则〈4,杀灭能力较低,对该病毒的灭活效果很难达到规范中的要求。结论过氧乙酸、碘伏以及复方二氯异氰尿酸钠对小鼠肝炎病毒的杀灭效果确实,适用于对小鼠肝炎病毒的消毒。

    Abstract:

    Objective To evaluate the efficacy for 4 disinfectants in inactivation of mouse hepatitis virus(MHV).Methods According to the 'Disinfectants Technical Guidelines',2002 ed,neutralization and MHV inactivation tests were used to evaluate their antiviral activity.Results After treatment with MHV-A59 for 5 min and 10 min,the inactivation logarithmic value of peracetic acid disinfectant,iodophor,sodium dichloroisocyanurate were higher than 4.The inactivation logarithmic value of benzalkonium bromide was lower than 4,indicating a low inactivation efficacy,which could not satisfy the requirements of guidelines.Conclusion Peracetic acid disinfectant,iodophor and sodium dichloroisocyanurate have good efficacy in inactivation of MHV-A59.

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冯洁,王胜昌,胡建华,高骏,孙凤萍,吴祖立.四种消毒剂对小鼠肝炎病毒MHV-A59的杀灭效果[J].中国比较医学杂志,2007,(4):219~222.

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  • 收稿日期:2006-07-07
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