Objective Since the outbreak of severe acute respiratory syndrome(SARS) in 2003,rapid progresses have been made in the development of SARS animal models.Several animal models including nonhuman primates,mice,hamster,civet and ferret all support SARS-CoV replication and some of them show pathological changes with different severity.However,present alternatives are not fully satisfied by absence of consistent clinical illness and pathological changes observed in humans with SARS.Because animal models play important roles in the entire process of SARS research,it is necessary to continuously develop more susceptible animal models for SARS.