Objective To explore the relationship between vascular calcification and hyperlipidmia and interfered with simvastatin.Method Thirty-six male SD rats were divided into six groups randomly: control group;vascular calcifid group;hyperlipidmia group;vascular calclfid group based on high lipid diet;vascular calcifid group therapid with simvastatin;vascular calcifid group based on high lipid diet tharopid with simvastatin.At the end of six weeks of drug administration,all rats were sacrificed.Total cholesterol and highdensity lipoprotein levels in serum and alkaline phosphate activity and total calcium content in aorta were measured and calcium deposit were observed by Von Kossa stain.Results With 288.89% and 259% increase in the total Ca~(2 ) content and ALP activity in aorta in vascular calcifid group than control group.With 520.11% increase in the total cholesterol and 22% decrease in the high-density lipoprotein cholesterol in serum in hyperlipidmia group than control group.With 36.49%,and 21.94% increase in the total Ca~(2 ) content and ALP activity in aorta,and 571.56% increase TC,30% decrease HDL in serum in vascular calclfid group based on high lipid diet than vascular calcifid group.Conclusion Simvastatin can alleviate vascular calcification,hyperlipidmia and vascular calcification are causes and effects each other.Simvastatin can postphone vascular calcification and reduce lipoprotein in serum at the same time.