Objective To investigate the influence of music on growth and development in mice. Method 30 ICR mice which were fed 27 days in music environment of 50 dB and 60 dB of Guzheng and Hulu hereby，were weighed once per 3 days，and were measured digestibility of various nutrients of feed once per 9 days. Result The body weights of female mice in different music environment were all higher than control group (P < 0. 05) ，and 50 dB groups were higherthan 60 dB groups in all music environment (P < 0. 05) . The body weights of male mice in Guzheng music environment were higher than that of control group ( P < 0. 05 ) . However the body weights of male mice in Hulu hereby music environment were lower than control group. The digestibility of various nutrients of mice had no significant difference in different music environment (P > 0. 05) . Conclusion Different music environment have a significant effect on the body weight of mice，and have no effect on the digestibility of various nutrients.