Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis infection，which is one of the major infectious diseases that are harmful to human health. The vaccine currently used，Bacille Calmette and Guerin (BCG) ，is effective in preventing the most severe disseminated forms of disease in children and newborns，but its efficacy against active TB in adults has been challenged by several clinical studies. In the last few years，the search for a new vaccine has obtained a new momentum. These recent advances in the clinical testing of new TB vaccines are very exciting and promising. However，there is a need to continue the search for additional vaccine candidates.