Objective To research the relationship of anger model and γ-aminobutyric acid B2 receptor (GABABR2) ，and the intervention mechanism of jingqianping granule by observing the differential expression of GABABR2 in anger emotional model rats of cerebral cortex regions and hippocampus. Methods The anger model was induced in rats by resident-intruder. We analyzed the expression of GABABR2 in cerebral cortex and hippocampus by Western Blot and RT-PCR. Results The expression of GABABR2 in cerebral cortex and hippocampus of model rats decreased obviously compared with the normal control group. Compared with the model group，the expression of GABABR2 increased after treated with Jingqianping graulne. Conclusion The Jingqianping granule can up-regulate the GABABR2 expression level of the model rats in cerebral cortex and hippocampus，which may be one of the mechanisms impacting rats with anger emotion. The expression changes of GABABR2 are tight related to rats with anger emotion.