Objective To establish a set of rabbit model of hepatic fibrosis，and summarize the experiences from the modeling process. Method 30 normal level rabbits were divided into two groups，25 rabbits as the experimental group were given carbon tetrachloride and oil mixture by intraperitoneal injection; five rabbits of the control group were given the same dose of saline. At 4th、7th、10th、13th、16th Week ，2 ～ 4 rabbits from the experimental group and 1 from the control group were sacrificed to observe the degree of hepatic fibrosis. Result During the modeling，seven rabbits of the experimental group were dead; the entire control group was survived. The degree of hepatic fibrosis was aggravated gradually with modeling extended. Conclusion The method successfully established a set of rabbit model of hepatic fibrosis.