Laboratory animal science is one of the fundemental and supporting subjects for life science researching work. When teaching laboratory animal science to medical students，we should center on standardization of laboratory animals and animal experiments，should add and consummate theoretical teaching stuff such as animal models，molecular genetics， embryo engineering and transgenic animals in order to follow up development trendency of life science. Meantime，we must integrate the theory with practice，and take full advantage of modern advanced teaching methods to nurture students′ operating skills and creative thinking with fundemental experiments，comprehensive experiments and autonomous design experiments. These exploration and improvement methods would have significant meaning for improving the quality of teaching laboratory animal science and intensifing students′ research ability in medical school.