The Studies on Catalase-2 of Biochemical Markers of Inbred Mice
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National Institute for Food and Drug Control，Beijing 100050，China
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摘要:
目的 为了进一步完善近交系小鼠遗传生化标记检测方法，对近交系小鼠过氧化氢酶-2 生化标记位点进行研究。方法 将 CBA /Ca 与 BALB / c 交配得到杂交 F1 代动物，同时将 CBA /Ca 与 C57BL /6 交配得到杂交 F1代动物，然后通过 F1 代动物之间的交配，以及 F1 代动物与母代的回交，得 到 F2 代 动 物，对 F2 代动物进行过氧化氢酶-2 生化标记检测。结果 在杂交 F1 代不表现的过氧化氢酶-2 的 b 型基因，在 F2 代出现。结论 近交系小鼠过氧化氢酶-2 遗传生化标记位点的等位基因 a 是完全显性的。
Abstract:
Objective To consummate genetic biochemical marker of inbred mice，we study Catalase-2 of biochemical markers of inbred mice． Methods Filial generation 1 CCBF1 were abtained by intercrossing of CBA /Ca and BALB / c; and filial generation 1 B6CBF1 were also abtained by intercrossing of CBA /Ca and C57BL /6． Filial generation 2 were obtained by intercrossing between filial generation 1 and by backcrossing between filial generation 1 and their parents．Then filial generation 2 were monitored by biochemical markers． Result Ce-2b is detected among filial generation 2 mice，while not among filial generation 1 mice． Conclusion Ce-2a is fully dominant．