Abstract:ObjectiveTo investigate prevention and cure effect of Ulinastatin(UTI) combined with XUEBIJING(XBJ) on multiple organ dysfunction syndrome(MODS) induced by lip polysaccharide (LPS) in sheep . Methods50 sheep were randomly separated into 5 groups :the control(Group A), model group (Group B), UTI group (Group C), XBJ group(Group D) and UTI + XBJ group (Group E), 10 sheep each group . The MODS model was established by LPS in sheep. It was prevented and cured by UTI, XBJ and UTI + XBJ. Then the physical sign appearance was observed and the indexes of blood gas, blood routine and blood biochemistry were determined in each group. ResultsThe sheep in UTI＋XBJ group, the physical sign appearance was obviously alleviative, the death rate was markedly degraded. Arterial oxygen pressure (PaO2), the biochemical indexes and the number of WBC was regulated efficiently. ConclusionUTI + XBJ could improve obviously physical sign appearance, degrade the death rate and it had favourable preventive and therapeutic effect on damage in multiple organ.