小型猪冠脉支架模型中即刻OCT检查评价支架贴壁不良的安全性和有效性
作者:
作者简介:

王天杰(1985),男,住院医师,博士,研究方向冠心病介入诊断及治疗。

基金项目:

卫生部部属(管)医院临床学科重点项目资助;国家自然科学基金(9,9);中国医药卫生事业发展基金(2008-zhfj2,2011-H25)。


Stent Malapposition Immediately after Stent Implantation:A Study from Optical Coherence Tomography Examination on Mini Pig Model
Author:
  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • | |
  • 文章评论
    摘要:

    目的评价中华小型猪冠状动脉支架植入术后即刻行光学相干断层成像扫描(OCT)的安全性和有效性。方法健康中华小型猪22只,经股动脉途径行右冠状动脉西罗莫司药物洗脱支架植入术,术后即刻行OCT检查评价支架贴壁不良情况,同时记录OCT检查时间和相关并发症。结果OCT共检查25段支架,失败3例(1例指引导丝断裂于支架内,2例发生冠脉痉挛导致阻断球囊送入困难未能成像),OCT检查并发症包括一过性ST段抬高(5例)和室颤(3例),死亡1例,平均手术时间49.7±12.9 min,其中OCT检查耗时17.9±4.9 min,OCT共检测522 mm支架,定量测量4514个支架丝,其中66个存在贴壁不良,即刻支架贴壁不良率1.46%。结论利用冠脉内OCT技术可以有效评价支架术后即刻贴壁不良情况,安全性良好。

    Abstract:

    ObjectiveTo investigate the safety and efficacy of immediately coronary optical coherence tomography (OCT) examination after stent implantation in the mini pig model. Methods Twenty-two health Chinese mini pigs were given percutaneous coronary stent implantation in right coronary artery. Stent strut malapposition was evaluated by OCT analysis. The duration and complication of OCT examination were recorded at the same time. ResultsOCT examination was performed on 25 stents and failed in 3 cases (1 pig had guiding wire fractured inside stent and 2 had coronary artery spasm and failed to deliver the occlusion balloon). Side effect contained 5 cases of temporarily ST segment elevation and 3 cases of ventricular fibrillation (2 pigs survived after successful electrical defibrillation and 1 dead). The mean duration of operation and OCT examination was 49.7±12.9 minutes and 17.9±4.9 minutes respectively. OCT detected 4514 stent struts and discovered 66 malapposition struts. And the rate of malapposition strut immediately after stent implantation was 1.46%. ConclusionOCT examination could be applied on mini pig stent implantation model with high quality and safety and was effective enough to evaluate the strut malapposition immediately after stent implantation.

    参考文献
    相似文献
    引证文献
引用本文

王天杰,杨跃进,唐跃,田毅,袁卫民,张骞,董秋婷,王红,金辰,李向东,徐辉.小型猪冠脉支架模型中即刻OCT检查评价支架贴壁不良的安全性和有效性[J].中国比较医学杂志,2012,(5):60~63.

复制
分享
文章指标
  • 点击次数:2675
  • 下载次数: 1614
  • HTML阅读次数: 0
  • 引用次数: 0
历史
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭