免疫衰老与T、B细胞改变的相关研究

doi:10.3969/j.issn.1671.7856.2012.06.015

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免疫衰老与T、B细胞改变的相关研究
DOI:
                        10.3969/j.issn.1671.7856.2012.06.015
                    
作者:
                        李彦红李彦红
中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021
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刘颖刘颖
中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021
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秦川秦川
中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021
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作者简介:李彦红(1983-),女,硕士生,研究方向:病理学与病理生理学。E-mail:liyanhong8408@163.com。
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基金项目:协和青年科研基金(慢性炎症性皮肤病KM小鼠自发突变模型的研究和培育)。

Correlational Research of Immunosenescence and the Change of T、B Cell

Author:

LI Yan-hong
LI Yan-hong
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine;Beijing Union Medicine College, Beijing 100021, China
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LIU Ying
LIU Ying
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine;Beijing Union Medicine College, Beijing 100021, China
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QIN Chuan
QIN Chuan
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine;Beijing Union Medicine College, Beijing 100021, China
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摘要:

胸腺、适应性免疫系统的T、B细胞及固有免疫系统中中性粒细胞、巨噬细胞、NK/NKT细胞、树突状细胞等免疫细胞与免疫衰老(immunosenescence)均存在一定相关性。免疫衰老主要涉及适应性免疫系统的改变,本文将从T、B细胞的数目、功能、表面分子、分泌的细胞因子及其信号转导等方面的改变进行总结。

关键词:免疫衰老; 适应性免疫; T、B细胞; 分子

Abstract:

There are some correlations between the variation of thymus,T、B cells of adaptive immune system, neutrophil, macrophage, NK/NKT cells, Dendritic cells etc of natural immune system and immunosenescence. Immunosenescence mainly associated with the varies of adaptive immune system, therefor, this article will introduce the inordinately varies of the number, surface molecules, cytokines and signal transduction as well as the dysfunction of T and B cell with age. 

Key words:Immunosenescence; Adaptive immunity; T、B cell; Molecule

参考文献

[1] Ademokun A, Wu YC, Dunn-Walters D.The ageing B cell population:composition and function[J].Biogerontology.0,1(2):125-137.

[2] Shanley DP, Aw D, Manley NR, et al.An evolutionary perspective on themechanisms of immunosenescence[J].Trends Immunol, 9,0 (7):374-381.

[3] Weiskopf D, Weinberger B, Grubeck-Loebenstein B.The aging of the immune system[J].Transpl Int.9,2(11):1041-1050.

[4] Aw D, Silva AB, Palmer DB.Is thymocyte development functional in the aged[J]? Aging, 9,1 (2):146-153.

[5] 何维等.医学免疫学[M].北京:人民卫生出版社,2005:181-200.

[6] Aspinall R.Andrew D.Thymic involution in aging[J].J Clin Immunol,0,0 (4):250-256.

[7] Min H, Montecino-Rodriguez E, Dorshkind K.Reduction in the developmental potential of intrathymic T cell progenitors with age[J].J Immunol,4,3 (1):245-250.

[8] Ferrando-Martínez S, Ruiz-Mateos E, Hernández A, et al.Age-related deregulation of naive T cell homeostasis in elderly humans[J].Age (Dordr).1,3(2):197-207.

[9] Gruver AL, Hudson LL, Sempowski GD.Immunosenescence of ageing[J].J Pathol.7,1(2):144-156.

[10] 宋淑霞,吕占军.T、B细胞衰老及其分子机制研究进展[J].细胞与分子免疫杂志.2,8(3):306-308.

[11] Wang L, Xie Y, Zhu LJ, Chang TT, et al.An Association between Immunosenescence and CD4+CD25+Regulatory T Cells:A Systematic Review[J].Biomed environ Sci, 0,3(4):327-332.

[12] Maria ST, Thomas LL, Florentine M, et al．Lake of antibody prauction Following immunization in old age:association with CD8+ CD28-T cell clonal expansions and an imbalance in the prauction of Thl and Th2[J].J Immunol, 2,9(6):5893-5901.

[13] Lang PO, Mitchell WA, Lapenna A, et al.Immunological pathogenesis of main age-related diseases and frailty:Role of immunosenescence[J].Eur Geriatr Med, 0,1(2):112-121.

[14] Saoulli K, Lee SY, Cannon JL, et al.CD28-independent,TRAF2-dependent costimulation of resting T cells by 4-1BB ligand[J].J Exp Med,8,7(11):1849-1862.

[15] 刘玉华,邸玉华.免疫老化与T细胞功能性分子的改变[J].细胞与分子免疫学杂志.9,5(7):98-100.

[16] Leng QB, Bentwich Z, Borkow G.CTLA-4 upregulation during aging[J].Mech of Age & Devel, 2,3(10):1419-1421.

[17] Channappanavar R, Twardy BS, Krishna P, et al.Advancing age leads to p redominance of inhibitory recep tor exp ressing CD4 T cells[J].Mech Ageing Dev, 9,0 (10): 709-712.

[18] Shimada Y, Hayashi M, Nagasaka Y, et al.Age-associated up-regu-lation of a negative co2stimulatory recep tor PD21 in mouse CD4+T cells[J].Exp Gerontol, 9,4 (8):517-522.

[19] Mountz JD, Wu JG, Zhou T, et al.Cell death and longevity:implications of Fas mediated apoptosis in T cell senescence[J].Immunol Rev, 7,0:19-30.

[20] Pahlavani MA, Vargas DA.Aging but not dietary restriction alters the activationinduced apoptosis in rat T cells[J].FEBS Lett, 1,1(1-2):114-118.

[21] 张宏娟, 王跃.T细胞衰老及分子机制的研究进展[J].国外医学.老年医学分册.2005,26(2):88-89.

[22] 侯麦花、许桦、杨丽萍.IL-2对正常人外周血活化淋巴细胞经Fas介导凋亡的影响[J].东南大学学报(医学版),2,1(4):296-299.

[23] O''Mahuny L,Holland J,Jackson, et al.Quantitative intracellular cytokine measurement:age-related changes in proinflammatory cytokine production[J].Clin Exp Immunol, 8,3(2): 213-220.

[24] Zhao Y, Wang Y, Liu JZ, et al.Changes of Foxp3 and IL-10 and TGF-beta in aging of mice[J].J Cell Mol Immunol.0,6(9):842-845.

[25] 何维等.医学免疫学[J].北京:人民卫生出版社,2005.245-248.

[26] Martinis DM,Franceschi C,Monti D,et al.Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity[J].FEBS Lett, 5,0:2035-2039.

[27] Miller RA.Effect of aging on T lymphocyte activation[J].Vaccine, 0,8 (16):1654-1660.

[28] Larbi A, Douziech N, Khalil A, et al.Effects ofmethyl-beta-cyclodextrin on T lymphocytes lipid rafts with aging[J].Exp Gerontol.4,9(4):551-558.

[29] Larbi A, Douziech N,Dupuis G,et el.Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes[J].J Leukoc Biol, 4,5(2):373-381.

[30] Colonna-Romano G, Bulati M, Aquino A, et al.B cell immunosenescence in the elderly and in centenarians[J].Rejuvenation Res.8,1(2):433-439.

[31] Johnson SA, Cambier JC.Ageing, autoimmunity and arthritis:Senescence of the B cell compartment—implications for humoral immunity[J].Arthritis Res Ther, 4,6(4):131-139.

[32] LeMaoult J, Szabo P, Weksler ME.Effect of age on humoral immunity,selection of the B-cell repertoire and B-cell development[J].Immunol Rev, 7,0 (1):115-120.

[33] Min H, Montecino-Rodriguez E, Dorshkind K.Effects of aging on the common lymphoid progenitorto pro-B cell transition[J].J Immunol, 6,6(2):1007-1012.

[34] Stephan RP, Sanders VM, Witte PL.Stage-specific alterations in murine B lymphopoiesis with age[J].Int Immunol,6,8(4):509-518.

[35] Gruver AL, Hudson LL, Sempowski GD.Immunosenescence of ageing[J].J Pathol.7,1(2):144-156.

[36] Charles A Janeway Jr, Paul Travels.Immunologie[M].Berlin:Garland Sciense, 2001.

[37] Bovbjerg DH, Kim YT, Schwab R, et al.“Cross-wiring”of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigen[J].Cell Immunol, 1,5 (5): 519-527.

[38] Ongrádi J, Kvesdi V.Factors that may impact on immunosenescence:an appraisal[J].Immun Ageing.0,7:7.

[39] Fietta P.The immunosenescence[J].Riv Biol, 8,1(2):247-263.

[40] Franceschi C, Bonafe M, Valensin S, et al.Inflamm-aging.An evolutionary perspective on immunosenescence[J].Ann N Y Acad Sci, 0,8:244-254.

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李彦红,刘颖,秦川.免疫衰老与T、B细胞改变的相关研究[J].中国比较医学杂志,2012,(6):65~71.

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