The Progress in Models of Human Cancer Stem Cell Xenografts
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摘要:
人肿瘤干细胞(human cancer stem cells, CSCs)分离后异种移植至模型内的成瘤特性,为研究肿瘤病因学和制订抗癌策略提供了新的手段和方法。但是,目前人肿瘤干细胞的鉴别离不开移植至异种免疫缺陷鼠内建立肿瘤干细胞的动物模型。本文主要从CSCs的概念、CSCs与肿瘤的关系、CSCs异种移植模型研究进展、模型建立的影响因素、模型建立存在的问题等进行简要综述,为异种移植模型的建立提供参考。
Abstract:
Human cancer stem cells (CSCs) represent promising tools for new approaches to cancer etiology studies and anti-cancer strategy. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells largely relies on models of xenograft transplantation into immunodeficient mice. Here we shortly review the knowledge on the concept of CSCs, the relationship between CSCs and tumors,the progress in the xenograft-model studies and the factors influncing the establishment of the CSCs models.