Abstract:Diabetic Nephropathy is well known as complication of microvessel disease caused by diabetes. High glucose leads to compensable high filtration rate of kidney,and then contribute to kidney cell groth, inflammation and fibrosis. Farnesoid X Receptor has been proved to ameliorate diabetic nephropathy. FXR can improve diabetic nephropathy through different aspects such as glucose, lipid, inflammation and fibrosis. How FXR improve diabetic nephropathy will be discussed in this review.