Objective To observe the anesthetic effect of Sumianxin Ⅱ combined with chloral hydrate in plastic surgical operation on rabbit and explore the fast, safe and effective anesthetic methods.Methods A total of 82 Rabbits for operation were randomly divided into A, B and C groups.The A group was injected with SumianxinⅡintramuscularly (0.35 mL/kg by weight). The B group was injected with 10% chloral hydrate intravenously (2.5～3 mL/kg by weight). The C group was injected with SumianxinⅡintramuscularly (0.2 mL/kg by weight) combined with 10% chloral hydrate intravenously(1～1.5 mL/kg by weight).The anesthetic effect of induction and recovery time of anesthesia,anesthesia maintaining time,and anesthesia mortality rate were observed and compared.Results The anesthetic effect of induction of anesthesia,recovery time of C groups fall in between which of A and B groups(P< 0.05).However, as for anesthesia maintaining time, there was no significant difference between A and C group and both the two groups were longer than B group.Conclusion SumianxinⅡcombined with chloral hydrate possess the advantages of fast anesthesia induction and recovery effect, longer anesthesia maintaining time and low mortality. Therefore it is an easy to operate, expeditious, safe and effective anesthetization for plastic surgical operation on rabbit.