目的 研究Beagle犬连续静脉注射给予丹红注射液13周后所产生的亚慢性毒性作用。方法 选取Beagle犬24只，分为4组，连续静脉给药13周，以体重、血液生化学、血液学、脏器重量、组织病理学检查为检测指标，综合评价丹红注射液对Beagle犬的毒性作用。结果 丹红注射液494 mg/kg组Beagle犬体重增长明显延缓，肾功能指标（BUN、CR）明显增加，组织病理学检查表明肝脏枯否细胞增生。结论 丹红注射液494 mg/kg剂量下连续静脉注射13周可致Beagle犬产生明显的肾脏和肝脏毒性。
Objective To investigate the subchronic toxicity of a Chinese medicine Danhong injection in dogs. Methods Twenty-four healthy Beagle dogs (body weigh 7-9 kg, male:female=1:1) were used in this study. The test dogs were administered with Danhong injection by intravenous injection once every day for consecutive 6 days/week for thirteen weeks. The Danhong injection was used in 3 doses: 494，247，and 124 mg·kg-1, repectively. The control dogs received normal saline injection in the same volume. The body weight, blood biochemistry, hematology, viscera relative weight and histopathology were determined for the overall toxicity assessment. Results The dogs administered with 494 g·kg-1 Danhong injection showed significantly reduced body weight gain, abnormal increase of urea nitrogen (BUN), creatinine (CR) levels, and histopathological changes in the liver. Conclusions Danhong injection (494mg·kg-1) administered Intravenously has obvious toxicity on the liver and kidney function.
迟福艳,薛云,戴学栋,马玉奎.丹红注射液对Beagle犬的13周亚慢性毒性试验[J].中国比较医学杂志,2014,24(6):27~29,34.
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