The cause of dilated cardiomyopthy (DCM) has not been elucidated yet. The poor prognosis and lack of specific and effective treatment became a serious health problem. Therefore to establish animal models of DCM to study the pathogenesis and treatment is necessary and urgent. At present the molding method of DCM mainly includes drug induction, immunological induction and molecular biology, etc. This article reviews the mature and commonly used establishing methods and mechanism of DCM models.