血管性痴呆大鼠模型的治疗方法研究进展
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北京市卫生系统高层次人才学科骨干项目(2013-3-092);北京市委组织部优秀人才工程(2012D005018000007)。


Therapeutic research progress in rat models of vascular dementia
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    摘要:

    血管性痴呆是引起认知障碍的常见原因,双侧颈总动脉结扎、大脑中动脉闭塞以及原发性高血压大鼠常被作为血管性痴呆模型加以研究。本文将对此类模型的药物及非药物治疗方法研究现状进行综述,从而为血管性痴呆的临床干预提供更多的科学参考建议。

    Abstract:

    Vascular dementia is one of the common causes of cognitive impairment. Occlusion of bilateral common carotid arteries, middle cerebral artery occlusion, as well as induced hypertension are major methods to make rat model for vascular dementia. The present review will summarize research progress in medical and non-medical treatment of vascular dementia rat models in order to provide theoretical direction for clinical practice.

    参考文献
    [1] Korczyn AD, Vakhapova V, Grinberg LT. Vascular dementia[J]. J Neurol Sci, 2012, 322: 2-10.
    [2] Ehrlich D, Humpel C. Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood-brain barrier leakage in rats in vivo[J]. Journal of the Neurological Sciences,2012,322: 92-95.
    [3] Tayebati SK, Tomassoni D, Amenta F. Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior[J]. Journal Of The Neurological Sciences,2012,322: 241-249.
    [4] Yamada K, Horita T, Takayama M, et al. Effect of a centrally active angiotensin converting enzyme inhibitor, perindopril, on cognitive performance in chronic cerebral hypo-perfusion rats[J]. Brain Research,2011,1421:110-120.
    [5] Kishi T, Hirooka Y, Sunagawa K. Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats[J]. Journal Of Cardiology,2012,60:489-494.
    [6] Sharma B, Singh N. Experimental hypertension induced vascular dementia: Pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor[J]. Pharmacology, Biochemistry and Behavior,2012,102:101-108.
    [7] Sain H, Sharma B, Jaggi AS, et al. Pharmacological investigations on potential of peroxisome proliferators-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in rats[J]. Neuroscience,2011,192:322-333.
    [8] Sharma B, Singh N. Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats[J]. Psychopharmacology,2011,215:677-687.
    [9] Xi Y, Wang M, Zhang W, et al. Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion[J]. Neurobiology Of Learning And Memory,2014,109: 7-19.
    [10] Tayebati SK, Di Tullio MA, Amenta F. Effect of Treatment with the Cholinesterase Inhibitor Rivastigmine on Vesicular Acetylcholine Transporter and Choline Acetyltransferase in Rat Brain[J]. Clinical and experimental hypertension,2004,26:363-373.
    [11] Tomassoni D, Catalani A, Cinque C, et al. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats[J]. Current Alzheimer Research,2012,9:120-127.
    [12] 黄树其, 牛富生, 邵福源. 促红细胞生成素对血管性痴呆大鼠海马CA1区胆碱乙酰转移酶的影响[J]. 中国老年学杂志,2012,32:3259-3261.
    [13] Ozacmak VH, Barut F, Ozacmak HS. Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats[J]. Journal of Pineal Research,2009,47:156-163.
    [14] Zhang LM, Jiang CX, Liu DW. Hydrogen Sulfide Attenuates Neuronal Injury Induced by Vascular Dementia Via Inhibiting Apoptosis in Rats[J]. Neurochemical Research,2009,34:1984-1992.
    [15] Wu CX, Liu R, Gao M, et al. Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis[J]. Neuroscience Letters,2013,546:57-62.
    [16] Zhang GZ, Liu A, Zhou Y, et al. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia[J]. Journal of Ethnopharmacology,2008,115:441-448.
    [17] Zhang L, Lü L, Chan WM, et al. Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis[J]. Neurochemical Research,2012,37:911-919.
    [18] Han HS, Jang JH, Jang JH, et al. Water extract of Triticum aestivum L. and its components demonstrate protective effect in a model ofvascular dementia[J]. Journal Of Medicinal Food,2010,13: 572-578.
    [19] Lee B, Choi EJ, Lee EJ, et al. The Neuroprotective Effect of Methanol Extract of Gagamjungjihwan and Fructus Euodiae on Ischemia-Induced Neuronal and Cognitive Impairment in the Rat[J]. Evidence-Based Complementary and Alternative Medicine,2011,8:1-9.
    [20] Feng Z, Lu Y, Wu X, et al. Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion[J]. Journal of Ethnopharmacology,2012,144:313-321.
    [21] Sonntag WE, Ramsey M, Carter CS. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging[J]. Ageing Research Reviews,2005,4:195-212.
    [22] Gong X, Ma M, Fan X, et al. Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia[J]. Neuroscience Letters,2012,513:20-24.
    [23] 叶建新,林航,穆军山,等. bFGF对血管性痴呆大鼠海马神经干细胞的影响[J]. 中国比较医学杂志,2009,19(11):1-5.
    [24] Stasiak A, Mussur M, Unzeta M, et al. The central histamine level in rat model of vascular dementia[J]. Journal of physiology and pharmacology,2011,62:549-558.
    [25] Hu X, Lu Y, Zhang Y, et al. Remote ischemic preconditioning improves spatial learning and memory ability after focal cerebral ischemia-reperfusion in rats[J]. Perfusion,2013,28:546-551.
    [26] Xu T, Gong Z, Zhu WZ, et al. Remote ischemic preconditioning protects neurocognitive function of rats following cerebral hypoperfusion[J]. International Medical Journal Of Experimental And Clinical Research,2011,17:299-304.
    [27] Zhang T, Yang QW, Wang SN, et al. Hyperbaric oxygen therapy improves neurogenesis and brain blood supply in piriform cortex in rats with vascular dementia[J]. Brain Injury,2010,24: 1350-1357.
    [28] Zhu Y, Zeng Y. Electroacupuncture Protected Pyramidal Cells in Hippocampal CA1 Region of Vascular Dementia Rats by Inhibiting the Expression of P53 and Noxa[J]. CNS Neuroscience & Therapeutics,2011,17:599-604.
    [29] Yang XB, Kou ST, Zheng KS. Effect of warmth-promotion needling on cerebral SOD, MDA and AChE in vascular dementia rats[J]. Acupuncture Research,2007,32: 170-173.
    [30] He F. Influences of electro-acupuncture at related jing-well points in rats with vascular dementia[J]. Journal Of Traditional Chinese Medicine,2012,32:238-242.
    [31] Yao ZH, Zhang JJ, Xie XF. Enriched environment prevents cognitive impairment and tau hyperphosphorylation after chronic cerebral hypoperfusion[J]. Current Neurovascular Research,2012,9:176-84.
    [32] 刘莉莉,刘合玉. 康复训练对血管性痴呆大鼠海马区血红素氧合酶-1 mRNA表达的影响[J]. 中国老年学杂志,2012,32:99-101.
    [33] 张辉,张昊昕,张朝东. 康复训练对血管性痴呆大鼠认知障碍影响的NMDAR1机制[J]. 中国老年学杂志,2007,27:949-951.
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于飞,孙永馨.血管性痴呆大鼠模型的治疗方法研究进展[J].中国比较医学杂志,2014,24(9):66~71.

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  • 最后修改日期:2014-06-11
  • 在线发布日期: 2014-10-10
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