The Himalayan marmot is unique wildlife resources of the Qinghai-Tibet plateau, because of its biological characteristics is widely used in biomedical research. According to the biological characteristics of the Himalayan marmot and quality control standards of laboratory animals, it was domesticated on the continuous research. This paper reviews research progress in recent years, to improve the understanding of the Himalayan marmot and promote its basic and applied research, let it become a laboratory animals recently.