Objective To establish a practical animal model of chronic metabolic syndrome (MS) and to investigate the correlation and pathological mechanism between hyperuricemia and glucose/lipid metabolism. Methods High fat purine diet + oteracil potassium were used to establish the MS model. Quail serum uric acid and triglyceride were tested every one/two weeks and other parameters were determined at the end of the procedure along with histopathology examination. Results Uric acid and triglyceride levels in serum were markedly enhanced by the long-term stimulation of high fat purine diet + oteracil potassium. Glucose tolerance test showed that the peak value of glucose and the area under curve in model group were higher than the others, as well as the insulin levels. Meanwhile, the modeling agents increased aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine and induced liver, kidney and artery injuries. These injuries were partially alleviated by bezafibrate or febuxostat. Conclusions The results of the present study suggest that high fat purine diet + oteracil potassium could induce a simple, stable and durable animal model of chronic metabolic disorders.