Objective To explore the possibility of two kind of minipigs as the animal model for metabolic syndrome. Methods Bama minipigs and Tibet minipigs were selected to measure their body weight, body size and metabolic syndrome-related parameters including blood lipid, blood sugar and free radical. Results Compared with Tibet minipigs, Bama minipigs was heavier in weight, shorter in length, larger in neck circumference and abdominal circumference, higher in obesity index, and what's more, the difference in female Bama minipigs was more significant. The levels of TC, LDL-C, HDL-C and TC were higher in female than in male. GLU levels in Bama minipigs was higher than that of Tibet minipigs, and with differences in female Tibet minipigs significantly, while the level of FRA and HbA1c in the Tibet minipig was higher than that of Bama minipigs, Insulin level in female Bama minipigs and male Tibet minipigs was respectively higher than the male Bama minipigs and female Tibet minipigs. MDA levels in female Bama minipigs was significantly higher than that of male Bama minipigs and Tibet minipigs, the level of SOD and GSH-Px in Bama minipigs was higher than that of Tibet minipigs. Conclusions Through the analysis of normal physiological parameters, such as body weight, body measurement, blood lipid, blood sugar and free radical, Bama minipigs tend to be obese; the level of blood fat of female is higher than that of male in two kind of minipigs; the level of blood sugar of Bama minipigs is higher than that of Tibet minipigs, but the ability of Bama minipigs to control blood sugar is better than Tibet minipigs; the ability of Bama minipigs to antioxide is better than Tibet minipigs. In short, according to the specific needs different kinds of minipigs are selected to use in the metabolic syndrome-related research and verified in actual modeling practices.