Objective To investigate the effects and mechanism of acupuncture combined with honeycomb on allergic rhinitis(AR)rat model. Methods AR rat model was induced by ovalbumin(OVA). AR rats were treated with acupuncture combined with honeycomb for ten days. Fluticasone propionate nasal spray was selected as positive control in the text. Behavior analysis were observed and the content of histamine, IgE, IFN-γand IL-4 in serum, the weight of nosal draingage and the number of eosinophils and mast cells, the index of spleen and thymus were detected to evaluate the effects of acupuncture combined with honeycomb on AR rats. Results Compared with model group, acupuncture combined with honeycomb treatment groups displayed markedly lower behavior scores, histamine, IgE and IFN-γ in serum, the weight of nosal draingage and the number of eosinophils and mast cells, the index of spleen as well as higher IL-4 in serum and index of thymus. Conclusion Acupuncture combined with honeycomb displayed significant effects on AR rat model.