复杂性状遗传CC小鼠信息资源及研究应用
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中央科研院所基本业务费(DWS200709,DWS201208,DWS201512);传染病科技重大专项(2009ZX10004-503)。


The Collaborative Cross mice resource information and application
Author:
  • KONG Qi

    KONG Qi

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Key Laboratory of Human Disease Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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  • XIA Xia-yu

    XIA Xia-yu

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Key Laboratory of Human Disease Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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  • QIN Chuan

    QIN Chuan

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Key Laboratory of Human Disease Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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    摘要:

    复杂性状遗传CC小鼠(CC小鼠)由不同遗传背景的小鼠品系杂交后,近交培育而成,用于研究人类复杂性状疾病和疾病的遗传差异。CC小鼠能体现不同小鼠亚种的遗传差异,其单核苷酸多态性是传统近交系小鼠的四倍。CC小鼠在生命科学与医学研究领域的应用越来越广泛。本文通过信息检索等方式对CC小鼠相关信息资源进行梳理,阐述了CC小鼠的起源、数据库、应用工具,以及研究领域等,以推动CC小鼠资源在中国得到广泛应用。

    Abstract:

    Collaborative Cross mice (CC mice) are series of inbred mice strains generated from hybrid strains of mice with different genetic background which used for human complex diseases and genetic diversity diseases studies. Genetic diversity of CC mice can reflect different mouse subspecies, the single nucleotide polymorphism is four times than traditional inbred mice. CC mice are more and more widely used in the field of life science and medical research. Based on information retrieval of CC mice, we introduced the related information resources of CC mice origin, database, application tools, and research results, to promote CC mice resources to be used widely in China.

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引用本文

孔琪,夏霞宇,秦川.复杂性状遗传CC小鼠信息资源及研究应用[J].中国比较医学杂志,2016,26(7):11~14,73.

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  • 最后修改日期:2016-04-05
  • 在线发布日期: 2016-07-28
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