MiRs display an important role in a variety of biological, physiological and pathological processes, including cell proliferation, differentiation, apoptosis, individual development, occurrence and progress of diseases. Recent studies have discovered that miR-424 is the significant regulatory factor of angiogenesis, and is involved in many diseases such as infectious diseases, vascular diseases, central nervous system diseases and genital system disease. This article reviews the expression, effect and possible mechanisms of miR-424 in non-tumorous diseases.