Fkbp51与应激相关疾病的研究进展
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国家重点基础研究发展(973)计划(2013CB945001);协和青年创新基金(3332015054)。


Regulation of the response to stress-related disorders by Fkbp51
Author:
  • ZHANG Ling-ling

    ZHANG Ling-ling

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS) & Comparative Medical Center, Peking Union Medical College(PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Disease Animal Models, State Administration of TraditionalChinese Medicine, Beijing 100021, China
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  • QIU Bin

    QIU Bin

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS) & Comparative Medical Center, Peking Union Medical College(PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Disease Animal Models, State Administration of TraditionalChinese Medicine, Beijing 100021, China
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  • YANG Zhi-wei

    YANG Zhi-wei

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS) & Comparative Medical Center, Peking Union Medical College(PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Disease Animal Models, State Administration of TraditionalChinese Medicine, Beijing 100021, China
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  • YONG Wei-dong

    YONG Wei-dong

    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS) & Comparative Medical Center, Peking Union Medical College(PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Disease Animal Models, State Administration of TraditionalChinese Medicine, Beijing 100021, China
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    摘要:

    应激反应是对机体面对紧迫与危险时产生的一系列非特异性生理和心理应答反应的总称。下丘脑-垂体-肾上腺(HPA)轴作为神经调节的中枢系统,在应激反应引起的一系列神经内分泌的改变中具有重要的调控作用。糖皮质激素受体(GR)是HPA轴维持稳态的重要调节因子。FKBP51作为一种与FK506结合的共伴侣蛋白,对GR和HPA轴的功能具有负向调节作用,这一调节功能需要伴侣蛋白(热休克蛋白Hsp90/70等)和FKBP52的共同参与。近年来通过大规模人类基因组的研究发现,Fkbp51在由应激引发的一系列精神和代谢紊乱疾病中具有重要的调节作用。本文将对Fkbp51在应激相关精神疾病以及物质代谢紊乱中的作用和影响进行综述。

    Abstract:

    Stress response is the process that our body produces a series of nonspecific physiological and psychological response when dealing with pressureand dangers. The hypothalamus-pituitary-adrenal (HPA) axis, as the central nervous system, plays a critical functional role in regulating stress response.Glucocorticoid receptor (GR) is an important regulatory factor for HPA axis's homeostasis, and its function needs to combine with heat shock protein(Hsp90/70) and co-chaperone proteins (FKBP51or FKBP52). FKBP51,a FK506-binding protein, is a negative regulatory of GR and HPA axis function. In recent years, Fkbp51 has been identified as a significant regulatory in the stress-related psychiatric and metabolic disorders. Here we will review the recent studies of Fkbp51 on stress-related psychiatric and metabolic disorders.

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张玲玲,邱彬,杨志伟,雍伟东.Fkbp51与应激相关疾病的研究进展[J].中国比较医学杂志,2016,26(11):90~94.

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  • 最后修改日期:2016-07-06
  • 在线发布日期: 2016-11-18
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