教育部中央高校基本科研业务费（N130420001）。
目的 探讨在大鼠子宫角安置瘘管导管的可行性。方法 对大鼠进行麻醉后，在近子宫体端子宫角放置瘘管导管，并进行组织病理学和妊娠功能的研究。结果 大鼠子宫内膜厚度瘘管模型组内瘘管留置侧子宫角（497.68±81.64）μm与对照组（537.90±77.29）μm和瘘管模型组内对侧子宫角（503.56±76.34）μm相比差异不显著（P>0.05）；大鼠胚胎植入数量瘘管模型组（9.67±1.95）个与对照组（12.15±2.06）个相比显著减少（P<0.05）；瘘管模型组内瘘管侧子宫角（5.83±3.54）个与对侧子宫角（6.17±3.67）个相比差异不显著（P>0.05）。结论 子宫角瘘管导管模型对大鼠子宫组织结构影响较小，能够满足向子宫腔内长期注射病原微生物或者化学药物等的试验要求。
Objective To explore the feasibility of catheter implantation in a rat model of uterine horn fistula.Methods The catheter was placed into the uterine horns at one side in the rats, then histopathology and pregnancy function were studied.Results The endometrial thickness of the fistula side in the fistula model group (497.68±81.64 μm) was not significantly different compared with the control group (537.90±77.29 μm) and the opposite side (503.56±76.34 μm) (P>0.05). The number of embryo breeding in the fistula model group (9.67±1.95) was significantly decreased compared with the control group (12.15±2.06). The number of embryo breeding of the fistula side (5.83±3.54) was not significantly different compared with the opposite side (6.17±3.67) (P>0.05).Conclusions The effect of catheter on uterine tissue and pregnancy function is minimal, and the model of uterine horn fistula applies to the requirement of long term injection of pathogenic microorganisms or drugs.
侯金龙,袁超文,黄欢宇,王国卿.大鼠子宫角瘘管模型的建立[J].中国比较医学杂志,2017,27(2):29~33.
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