抑郁症动物模型的研究进展
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上海市进一步加快中医药事业发展三年行动计划(编号:ZY3-CCCX-3-2007)。


Research progress on animal models of depression
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    摘要:

    近年来抑郁症发病率逐年上升,严重危害了人类的身心健康,但是其发病机制尚未明确。而动物模型可以模拟人类抑郁症的疾病状态,被广泛运用于抑郁症发病机制研究和抗抑郁新药的研发。抑郁症动物模型根据造模方式不同可以分为以下几类:应激造模,手术造模,药物诱发造模和遗传造模。这些模型可以从不同的方面来解释抑郁症的发生,比如神经递质及其受体和转运蛋白、神经营养因子、神经内分泌系统、炎症假说等,在抑郁症的研究中发挥重要作用。该综述就常用的啮齿类动物抑郁症模型进行概述和评价,为抑郁症的研究提供参考。

    Abstract:

    The incidence of depression has been increasing over the recent years, which can cause serious physical and mental health problems in humans, but its pathogenesis has not been fully clarified. Animal models can simulate the depression in humans, thus are widely used for studies of the pathogenesis of depression, as well as in research and development of new antidepressants. According to the different ways of modeling, animal models of depression can be divided into the following categories:stress models, surgical models, drug-induced models and genetic models. These models can provide useful tools to explain some pathogenetic aspects of depression, such as neurotransmitters and their receptors/transporters, neurotrophic factors, neuroendocrine systems, inflammatory hypotheses, and so on. This review summarizes and evaluates the commonly used rodent animal models of depression and provides a reference for further research on depression.

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    [25] Aboul-Fotouh S. Chronic treatme?浴椠汷摩?獨琠牣敯獥獮孺?嵭??偑栱礰琠潲浥敶摥楲捳楥湳攠???ぴ?????㈠????????????????扮牨?孤??嵩??慡湮杤?剥???慮楣????婲桡慩湮朠????散瑨?慮汤???祬猠牲敥杳異汩慲瑡楴潯湲?漠晣?乡敩畮爠敡杮畤氠楣湲????牮扥??獩楮条湳慥氠楡湣杴?楶湩?瑩桥敳?灩牮攠晲牡潴湳瑛慊汝?挠潂牥瑨敡硶?慐湨摡?桭楡灣灯潬挬愠洲瀰由猳?漠昲?爨愷琩猺‵攵砲瀭漵猶攰搮?瑢潲 ̄捛栲父潝渠楖捯?畲湨灥牥敳搠楊捌琬愠扔污敲?洠楁汊搬?獗瑯牨敬獥獢嬠?嵓??健桴礠獡楬漮氠??敯桬慯癮??????????????????び??扩牮?孲??嵳?噳攠瑉界氭愶測椠?????慥牳氠祉?洭愱琰攬爠湡慮汤?獣敡灵慳牥慳琠楰潥湲?慩?牴潥摮整渠瑤?浰潲摥敳汳?潶晥?摬敩火牥攠獢獥楨潡湶?慯湲搠?慨?灴爠敩癳愠楲汥楶湥杲?桥畤洠慢湹?捲潥湣摯業瑢楩潮湡孮?崠??倭栱愰牛浊慝挮漠汐?副敓瀠????ㄠ?????????ㄩ??????????扲爾?嬲??崠?偲汢潵瑲獵欠祍?倠????敬慥湯敮礠??????慵牣汥祡??瀠潅猬琠湥慴琠慡汬?攠硃灨敲牯楮敩湣挠敭?慬汤琠敳牴獲?桳祳瀠潡瑮桤愠汩慭浩楰捲?捭潩牮瑥椠捴潲瑥牡潴灭楥湮?爠敥汬敩慣獩楴渠杯?晰慯捳瑩潴牥???剡???浳删乩???浥敨摡楶慩湯?攠浡楮湤攠湩据攠??剮??捥潸湰瑲敥湳瑳?慯湮搠?獮琠牴敨獥猠?楯湵摳略挠数摲?牦敲汯敮慴獡敬?楣湯?慴摥畸汛瑊?爮愠瑐獨孡?嵭???牬愠楂湩?剣敨獥??潂汥??牶愬椠渲‰刱攵猬??????????????????有?そ??扨牲?孳??嵡??牥慮挠楓慌?删畈戦椣漲?????潡獡捲潤猠潋??慗獩瑢牯潲????倠潥穴漠?佬???敩瑳?慵汲???愠瑤敩牵湲慮污?猠敲灨慹牴慨瑭椠潯湦?楴湨摲略捥攠獣?湡敳畳物潣楡湬映汰慨浡浳慥琠業潡湲?慥湲摳?汩潮渠杴?汥愠獣瑨楲湯杮?散洠潭瑩楬潤渠慳汴?慥汳瑳攠牲慡瑴椠潭湯獤?楬渠?浦椠捤敥孰?嵥??偩牯潮杛?九攮甠牎潥灵獲祯捳档潩瀠桒慥牳洬愠挲漰氱??椠漱氱‰债猴礳挭栴椸愮琼牢祲??有?????????づ??ㄠ????扡牶?孮??嵅?匠慐摡数杰栠楍????倠敡敬爮椠?????潩獣猠敭楩湬楤??????摳漭汩敮獤捵散湥瑤?癡潬汴略湲瑡慴物祯?敳砠敯牦挠楣獬敯?慫琠瑧敥湮略愠瑥數摰?桥楳灳灩潯据愠浩灮愠汲?楴渠湰慲瑥敦?楯浮浴畡湬椠瑣祯?牴敥獸瀺潭湯獤敵獬?慴湯摲?搠敥灦牦敥獣獴楳瘠敯?氠楰歲敯?扯敮桧慥癤椠潬牵獲?晳潩汤汯潮睥椠湴杲?浡慴瑭敥牮湴慛汊?献攠灐慨牡慲瑭楡潣湯?猠瑒牥敳猬猠′椰渱?洬愠氱攰?爺愱琴猰嬭?崵??值桢祲猾楛漳氰??敔桨慥癩???の????ㄠ????????????扒牨?孩??嵍?夠略慴渠?呬???卥汨潡瑶湩楯捲歡?????剦潥汲敥獮?潥晳?潯汦映慭捡瑬潥爠祗?獳祴獡瑲攠浲?摴祳猠晦畲湯捭琠楤潩湦?楥湲?摮整瀠牶敥獮獤楯潲湳嬠?嵮??偵牬潮来?乡敢畩牬潩灴獹礠捡桮潤瀠桲慥牳浩慬捩潥汮??椠潴汯?偣獨祲捯桮楩慣琠牭祩??㈠び???????????づ??扥牣?孥??嵩?传扥慰????乥慴歩慣朠慲睥慧獵慬楡?佩??传湡潮杤椠????敥瑳?慩汯???桦爠潰渱椱捛?晝氮甠療潲硡慩浮椠湒敥?琬爠攲愰琱洶攬渠琱?挴栲愺渵朰攵猭‵???吼?獲甾扛?㈱??????獯甠扃??爠敊捥敳灳瑥漠牃?洬攠摄楯慮瑡整摯?扆攬栠慥癴椠潡牬?椠湃?潲汯普慩捣琠潵牮祰?扥畤汩扣整捡瑢潬浥椠穭敩摬?洠楳捴敲孥?嵳???楣晲敥?即捥楳???ぎ?????㈠?????????????扤爠?孡??嵵??椫爼漯獳敵?举??匼慳極瑰漾栫?????愾洭敁楔?????湡癣潴汩癶敩浴敹渠瑩?漠晴?来氠畨瑩慰浰慯瑣敡牭杰極捳?乡?浤攠瑰桲祥汦???慴獡灬愠牣瑯慲瑴敥?爠敯捦攠灭瑩潣牥猺?楮湴?瑤桥数?敥硳灳牡敮獴猠楥潦湦?潣晴?楯湦挠牣敨慲獹敳摩?桛敊慝搮?摎楥灵灲楯湳杣?扥敮档慥瘬椠漲爰猱‵椬渠′琸根攺″栶漷氭攳?戰漮愼牢摲 ̄瑛攳猲瑝猠?潥晳?潲汩晣慯挠瑁潐爬礠?扡畲汴扯敲捩琠潇洬椠穂敲搦?洲椵挲攻孮?嵮???敁栬愠癥??牡慬椮渠?删敮獯??????????????????は??扯牵?孤??嵢?坬楩敳牨潥??????獮歩慣??????敤杩畣瑴歡潢?????畬摤礠獳????敳琭?慮汤??佥汤映慤捥瑰潲牥祳?扩當汥戭敬捩瑫潥洠祢?慨湡摶?慯浲椠瑩牮椠灭瑩祣汥楛湊敝?琠牂敥慨瑡浶攠湂瑲?楩湮映汒略敳測挠攲猰?洶?氠申‰爷攺挷攳瀭琸漳爮猼?敲砾灛爳攳獝猠楘潩湮?椠湈?琠桚敨?浮潧甠獋攬?扚牨慡楮湧?桒椬瀠灥潴挠慡浬瀮甠獁孮?嵩??偰桲慥牳浳慡据潴氭?剩敫灥???てづ????て?????????????扴牲?季??嵯??整楨瑥栠?乩????慣牯牭敢瑩瑮?剴????景晦攠捇瑡獲?潥普?捡栠牪潡湳業捩?慯浩灤桥敳琬愠浃楩湴敲?潳爠?牵敲獡敮牴灩極湭攠?潮湤?獍敡汧普?獬瑩楡洠畯汦慦瑩楣潩湮?牬敩獳瀠潩湮搠楡渠杲?慴渠業浯慤汥?洠潯摦攠汣?潲景?摩散瀠牵敮獰獲楥潤湩?孴?嵢??倀猀礀挀栀漀瀀栀愀爀洀愀挀漀氀漀最礀???攀爀氀?????? ??????????????戀爀?嬀??崀??愀爀爀??????愀爀欀漀甀????倀猀礀挀栀漀猀琀椀洀甀氀愀渀琀?眀椀琀栀搀爀愀眀愀氀?愀猀?愀渀?椀渀搀甀挀椀渀最?挀漀渀搀椀琀椀漀渀?椀渀?愀渀椀洀愀氀?洀漀搀攀氀猀?漀昀?搀攀瀀爀攀猀猀椀漀渀嬀?崀??一攀甀爀漀猀挀椀??椀漀戀攀栀愀瘀?刀攀瘀???  ???????????????? ???戀爀?嬀??崀?伀瘀攀爀猀琀爀攀攀琀?????吀栀攀?昀氀椀渀搀攀爀猀?猀攀渀猀椀琀椀瘀攀?氀椀渀攀?爀愀琀猀?愀?最攀渀攀琀椀挀?愀渀椀洀愀氀?洀漀搀攀氀?漀昀?搀攀瀀爀攀猀猀椀漀渀嬀?崀??一攀甀爀漀猀挀椀??椀漀戀攀栀愀瘀?刀攀瘀?????????????????????戀爀?嬀??崀?伀瘀攀爀猀琀爀攀攀琀??????爀椀攀搀洀愀渀?????愀琀栀???????????攀琀?愀氀??吀栀攀??氀椀渀搀攀爀猀?匀攀渀猀椀琀椀瘀攀??椀渀攀?爀愀琀?愀?猀攀氀攀挀琀椀瘀攀氀礀?戀爀攀搀?瀀甀琀愀琀椀瘀攀?愀渀椀洀愀氀?洀漀搀攀氀?漀昀?搀攀瀀爀攀猀猀椀漀渀嬀?崀??一攀甀爀漀猀挀椀??椀漀戀攀栀愀瘀?刀攀瘀???  ????????????????????戀爀?嬀??崀?伀瘀攀爀猀琀爀攀攀琀?????圀攀最攀渀攀爀????吀栀攀??氀椀渀搀攀爀猀?匀攀渀猀椀琀椀瘀攀??椀渀攀?爀愀琀?洀漀搀攀氀?漀昀?搀攀瀀爀攀猀猀椀漀渀????礀攀愀爀猀?愀渀搀?猀琀椀氀氀?瀀爀漀搀甀挀椀渀最嬀?崀??倀栀愀爀洀愀挀漀氀?刀攀瘀??? ???????????????????戀爀?嬀??崀?伀瘀攀爀猀琀爀攀攀琀??????漀搀攀氀椀渀最?搀攀瀀爀攀猀猀椀漀渀?椀渀?愀渀椀洀愀氀?洀漀搀攀氀猀嬀?崀???攀琀栀漀搀猀??漀氀??椀漀氀??? ?????????????????戀爀?嬀??崀?一愀洀?????氀椀渀琀漀渀?匀????愀挀欀猀漀渀?一???攀琀?愀氀???攀愀爀渀攀搀?栀攀氀瀀氀攀猀猀渀攀猀猀?愀渀搀?猀漀挀椀愀氀?愀瘀漀椀搀愀渀挀攀?椀渀?琀栀攀?圀椀猀琀愀爀??礀漀琀漀?爀愀琀嬀?崀???爀漀渀琀??攀栀愀瘀?一攀甀爀漀猀挀椀??? ??????? ???戀爀?嬀? 崀??愀挀漀戀猀攀渀??倀???攀搀瘀攀搀攀瘀??伀???愀爀漀渀?????吀栀攀????吀?搀攀昀椀挀椀攀渀挀礀?琀栀攀漀爀礀?漀昀?搀攀瀀爀攀猀猀椀漀渀?瀀攀爀猀瀀攀挀琀椀瘀攀猀?昀爀漀洀?愀?渀愀琀甀爀愀氀椀猀琀椀挀????吀?搀攀昀椀挀椀攀渀挀礀?洀漀搀攀氀??琀栀攀?琀爀礀瀀琀漀瀀栀愀渀?栀礀搀爀漀砀礀氀愀猀攀???猀甀瀀??爀最??猀甀瀀?????猀甀瀀??椀猀??猀甀瀀??欀渀漀挀欀椀渀?洀漀甀猀攀嬀?崀??倀栀椀氀漀猀?吀爀愀渀猀?刀?匀漀挀??漀渀搀????椀漀氀?匀挀椀??? ?????????? ??????????????戀爀?嬀??崀?吀椀稀愀戀椀?夀???愀甀猀攀爀?匀刀??吀礀氀攀爀??夀??攀琀?愀氀???昀昀攀挀琀猀?漀昀?渀椀挀漀琀椀渀攀?漀渀?搀攀瀀爀攀猀猀椀瘀攀?氀椀欀攀?戀攀栀愀瘀椀漀爀?愀渀搀?栀椀瀀瀀漀挀愀洀瀀愀氀?瘀漀氀甀洀攀?漀昀?昀攀洀愀氀攀?圀?夀?爀愀琀猀嬀?崀??倀爀漀最?一攀甀爀漀瀀猀礀挀栀漀瀀栀愀爀洀愀挀漀氀??椀漀氀?倀猀礀挀栀椀愀琀爀礀??? ? ???????????????戀爀?嬀??崀??礀攀爀攀洀愀渀琀攀渀最?????愀洀攀猀?????愀挀欀愀礀????攀琀?愀氀????猀琀甀搀礀?漀昀?戀爀愀椀渀?愀渀搀?猀攀爀甀洀?戀爀愀椀渀?搀攀爀椀瘀攀搀?渀攀甀爀漀琀爀漀瀀栀椀挀?昀愀挀琀漀爀?瀀爀漀琀攀椀渀?椀渀?圀椀猀琀愀爀?愀渀搀?圀椀猀琀愀爀??礀漀琀漀?爀愀琀?猀琀爀愀椀渀猀?愀昀琀攀爀?攀氀攀挀琀爀漀挀漀渀瘀甀氀猀椀瘀攀?猀琀椀洀甀氀甀猀嬀?崀??倀栀愀爀洀愀挀漀瀀猀礀挀栀椀愀琀爀礀??? ??????????????????
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张磊阳,贺敏,李玥,裘福荣,陈文文,吴雨,杨蒋伟,蒋健.抑郁症动物模型的研究进展[J].中国比较医学杂志,2017,27(9):92~97.

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  • 收稿日期:2016-12-27
  • 在线发布日期: 2017-09-23
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