国家自然科学基金资助项目（81173449）。
急性心肌梗死是危害人类生命的重大疾病之一。心肌梗死动物模型对研究人类心肌梗死的病理生理变化、诊断和治疗有着重要意义。目前心肌梗死动物模型的制备主要存在动物存活率低、繁琐复杂等问题。近年来，针对心肌梗死动物模型制备方法研究取得一些进展，在模型动物存活率、模型动物合格率、制备模型速度等方面具有一定的提高。该文就急性心肌梗死模型的制备方法及相关研究现状进行分析，结合实际因素以期简化模型制备过程，提高科研人员的造模水平，从而为医学研究提供稳定可靠的急性心肌梗死模型来源。
Acute myocardial infarction is one of the major causes of death in the world. Research on animal models of myocardial infarction has a great significance in improving the pathophysiology, diagnosis and treatment of human myocardial infarction. At present, problems such as low survival rate and complicated preparation still exist. In recent years, some progress has been made in the preparation of animal myocardial infarction models, which can improve the survival rate, qualified rate and speed. This paper analyzes the preparation of rat models of acute myocardial infarction and related research, combined with actual factors to simplify the process of preparation and improve the skills of scientific researchers, so as to provide a source of stable and reliable acute myocardial infarction models for medical research.
曹珏,李贻奎,陈孟倩,姚魁武.大鼠急性心肌梗死模型制备方法研究进展[J].中国比较医学杂志,2017,27(10):96~100.
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