唾液酸黏附素Siglec-1在疾病中作用的研究进展
作者:
基金项目:

国家科学项目自然基金,青年科学基金项目(81301437);科技部重大专项(2014ZX10001OO1-001-004,2014ZX10001OO1-002-006)。


Advances in research on the role of Siglec-1 in diseases
Author:
  • LI Ke-lei

    LI Ke-lei

    Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • LI Xiang

    LI Xiang

    Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • CONG Zhe

    CONG Zhe

    Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • XUE Jing

    XUE Jing

    Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • | |
  • 文章评论
    摘要:

    唾液酸黏附素(Siglec-1或CD169)是表达于组织的巨噬细胞上免疫球蛋白超家族类黏附分子。在炎症反应中,Siglec-1可调节MIP-1α/β、MCP-1、MIP-2等细胞因子的分泌,促进炎症反应的发生;在病毒感染过程中,Siglec-1可通过介导病原体与巨噬细胞的的结合,促进病毒感染和吞噬;在对免疫的调节过程中,Siglec-1既可也以抑制IFN-α的过量表达,抑制固有免疫,也可抑制DC细胞活性,降低适应性免疫。本文主要阐述了Siglec-1在病原体感染、炎症反应和免疫调节中最新研究进展。

    Abstract:

    Sialoadhesin (Siglec-1 or CD169) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets. In inflammatory response, Siglec-1 can modulate the secretion of MIP-1 alpha/beta, MCP-1, MIP-2 and other cytokines, and promote the occurrence of inflammatory reaction. During viral infection, Siglec-1 can promote the infection and phagocytosis of virus by mediating the binding of pathogens and macrophages. In the regulation of immunity, Siglec-1 can regulate innate immunity and adaptive immunity, by inhibiting the excessive expression of IFN-α and the activation of DC cells. This review mainly focuses on the new advances of research on Siglec-1 in pathogen infections, inflammation and immunoregulation.

    参考文献
    相似文献
    引证文献
引用本文

李克雷,李想,丛喆,薛婧.唾液酸黏附素Siglec-1在疾病中作用的研究进展[J].中国比较医学杂志,2017,27(12):109~114.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2017-06-01
  • 在线发布日期: 2017-12-16
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭