Objective To explore the effect of a Chinese Medicine Xionggui Liujunzi Decoction on the experimental coronary heart disease in rats. Methods Rats were randomly divided into five groups: the blank control group, the model control group, the western medicine control group (simvastatin), the Chinese medicine control group (compound Danshen dripping pills) and the Xionggui Liujunzi Decoction group. The coronary heart disease was induced by intragastric gavage of fat emulsion (10 mL/ kg, q. d. for 12 weeks) and pituitrin (30 U/ kg, q. d. for 3 days) was intraperitoneally injected to induce coronary artery spasm. Changes of the ST segment in electrocardiogram (ECG) and the blood lipids were detected, and the levels of the inflammatory factors including tumor necrosis factor-α ( TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), highly sensitive C-reactive protein ( hs-CRP), monocyte chemotactic protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1), the vascular endothelial active substances including ET-1, NO, TXA2 and PGI2, and the indicators of fibrinolytic system function such as PAI-1, t-PA in the plasma were measured. Results Compared with the model control group, each drug treatment showed better effects on the ST segment of the electrocardiogram, blood lipids, levels of the inflammatory factors and vascular endothelial active substances, and the fibrinolytic function, with significant differences ( P < 0.05). In particular, Xionggui Liujunzi Decoction has a significantly better effect than the compound Danshen dripping pills and simvastatin (P < 0.05). Conclusions Xionggui Liujunzi Decoction can improve the ST segment of the electrocardiogram, blood lipids, levels of the vascular endothelial active substances and fibrinolytic function of the rat model of coronary heart disease, and alleviate inflammation responses, showing a significant effect on coronary arteriosclerosis and myocardial ischemia in rats.