脑内表达的CYP450 基因参与内源性物质代谢

doi:10.3969/j.issn.1671-7856.2018.01.020

首页 > 过刊浏览>2018年第28卷第1期 >113-117. DOI:10.3969/j.issn.1671-7856.2018.01.020

脑内表达的CYP450 基因参与内源性物质代谢
DOI:
                        10.3969/j.issn.1671-7856.2018.01.020
                    
作者:
                        杨辛兰杨辛兰
中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫计委人类疾病比较医学重点实验室,北京 100021
在期刊界中查找
在百度中查找
在本站中查找
吕丹吕丹
中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫计委人类疾病比较医学重点实验室,北京 100022
在期刊界中查找
在百度中查找
在本站中查找
张连峰张连峰
中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫计委人类疾病比较医学重点实验室,北京 100023
在期刊界中查找
在百度中查找
在本站中查找

                    
作者单位:(中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫计委人类疾病比较医学重点实验室,北京 100021)
作者简介:
通讯作者:
中图分类号:R-33
基金项目:北京市自然科学基金(编号:5172027);国家自然科学基金(编号:31301932)?

Research progress of CYP450 genes expressed in brain involved in the metabolism of endogenous substances

Author:

YANG Xinlan
YANG Xinlan
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China
在期刊界中查找
在百度中查找
在本站中查找
LV Dan
LV Dan
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China
在期刊界中查找
在百度中查找
在本站中查找
ZHANG Lianfeng
ZHANG Lianfeng
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China
在期刊界中查找
在百度中查找
在本站中查找

Affiliation:

(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China)

Fund Project:

摘要

图/表

访问统计

参考文献

相似文献

引证文献

资源附件

文章评论

摘要:

细胞色素P450(cytochrome P450,CYP450)为一类亚铁血红素蛋白超家族,其参与多种内源性及外源性物质(食物成分?药物及污染物等)的代谢与活化?关于CYP450 基因,以往的研究主要集中在药物代谢方面,近年来的研究发现CYP450 家族成员的作用不仅仅局限于药物代谢,还参与多种疾病的发生及发展进程,包括帕金森病(Parkinson’s disease,PD)?癌症?心肌病及心衰等?目前,关于脑组织内CYP450 家族成员参与内源物质代谢的过程及机制尚不十分清楚?本文特总结了脑内表达的CYP450 基因对机体内源物质代谢的研究进展,以期为探索脑内表达的CYP450 基因的作用提供新的思路?

关键词:脑组织;细胞色素P450;内源物质;代谢

Abstract:

Cytochrome P450 (CYP450) is a superfamily of heme?thiolate proteins, which is involved in the metabolism and activation of various endogenous and exogenous substances, including food, drugs and pollutants. Previous studies of the CYP450 genes mainly focused on their function in drug metabolism. However, in recent years, studies have found that CYP450 are also involved in the development and progression of various diseases, including Parkinson’s disease (PD), cancer, cardiomyopathy and heart failure (HF). By far, the process and related mechanisms of CYP450 in the metabolism of endogenous substances in brain tissues has not been clarified yet. In this paper, we summarized the research progress of CYP450 genes involved in the metabolism of endogenous substances, in order to provide a new idea for the exploration of the functions of CYP450 genes expressed in the brain.

Key words:brain tissues; cytochrome P450; endogenous substances; metabolism

引用本文

杨辛兰,吕丹,张连峰.脑内表达的CYP450 基因参与内源性物质代谢[J].中国比较医学杂志,2018,28(1):113~117.

复制

文章指标

点击次数:
下载次数:
HTML阅读次数:
引用次数:

历史

收稿日期:2017-08-04
最后修改日期:
录用日期:
在线发布日期: 2018-02-02
出版日期:

首页

期刊介绍

编委会

作者须知

出版政策

期刊订阅

广告合作

联系我们

English

引用本文

分享

文章指标

历史