P301L突变tau蛋白转基因动物模型及其应用
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作者单位:

(首都医科大学宣武医院药物研究室,北京市老年病医疗研究中心,神经变性病教育部重点实验室,北京市神经药物工程研究中心,北京 100053)

中图分类号:

R-33

基金项目:

国家自然科学基金项目(编号:81673406);北京市科技专项(编号:Z131102002813066);北京市高层次卫生技术人才计划(编号:2011?1?7);首都卫生发展科研专项(编号:首发2016?2?1033)


P301L tau transgenic animal models and their applications
Author:
  • MA Denglei

    MA Denglei

    Department of Pharmacology, Xuanwu Hospital of Capital Medical University; Beijing Geriatric Medical Research Center; Key Laboratory of Neurodegenerative Diseases of Ministry of Education; Beijing Engineering Research Center of Nerve System Drugs, Beijing 100053, China
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  • ZHANG Ruyi

    ZHANG Ruyi

    Department of Pharmacology, Xuanwu Hospital of Capital Medical University; Beijing Geriatric Medical Research Center; Key Laboratory of Neurodegenerative Diseases of Ministry of Education; Beijing Engineering Research Center of Nerve System Drugs, Beijing 100053, China
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  • LI Lin

    LI Lin

    Department of Pharmacology, Xuanwu Hospital of Capital Medical University; Beijing Geriatric Medical Research Center; Key Laboratory of Neurodegenerative Diseases of Ministry of Education; Beijing Engineering Research Center of Nerve System Drugs, Beijing 100053, China
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Affiliation:

(Department of Pharmacology, Xuanwu Hospital of Capital Medical University; Beijing Geriatric Medical Research Center; Key Laboratory of Neurodegenerative Diseases of Ministry of Education; Beijing Engineering Research Center of Nerve System Drugs, Beijing 100053, China)

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    摘要:

    微管相关蛋白tau在阿尔茨海默病(Alzheimer’s disease,AD)等多个tau 蛋白病(tauoPathies)的发病机制中发挥重要的作用,并且得到了越来越多的关注?在tau蛋白病的研究中,理想的tau 蛋白病变模型对于发病机制和药物治疗的研究具有重要的意义?目前国内外学者已经建立了多个tau 蛋白转基因动物模型,其中过表达P301L突变tau蛋白的动物模型因具有明显的病理改变而得到广泛的应用?本文综述了P301L突变tau蛋白转基因动物模型的病理表现及在药理研究中应用的新进展?

    Abstract:

    Tau protein, a kind of microtubule?associated protein, plays an important role in the pathogenesis of Alzheimer’s disease (AD) and other tauopathies, and has drawn more and more attention of scientific researchers.Appropriate animal models of mutated tau protein are important in the studies of the pathogenesis and drug therapy of tauopathies. So far, some transgenic animal models expressing human tau protein have been established, among which the transgenic animal model overexpressing P301L mutated form of tau protein has been widely used because of its obvious pathological changes. In this review, we will review the research progress in the pathological manifestations of the P301L tau transgenic animal model and its applications in pharmacological studies.

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引用本文

马登磊,张如意,李林.P301L突变tau蛋白转基因动物模型及其应用[J].中国比较医学杂志,2018,28(1):123~128.

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  • 收稿日期:2017-08-09
  • 在线发布日期: 2018-02-02
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