小胶质细胞在神经发育和神经退行性疾病中的吞噬作用与调节机制
作者:
作者单位:

(1. 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫计委人类疾病比较医学重点实验室,北京 100021; 2. 中国医学科学院神经科学中心,北京 100730)

作者简介:

lijingwen_pumc@163. com

中图分类号:

R-33

基金项目:

中国医学科学院医学与健康科技创新工程(2016-I2M-1-004);北京市自然科学基金面上项目(7172135)


Phagocytic function of microglia and underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases
Author:
  • LI Jingwen 1

    LI Jingwen

    Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China
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  • ZHANG Li 1

    ZHANG Li

    Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China
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  • ZHANG Lianfeng

    ZHANG Lianfeng

    1. Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China. 2. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730
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Affiliation:

(1. Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China. 2. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730)

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    摘要:

    小胶质细胞是神经胶质细胞的一种,具有吞噬?清除?抗原提呈?促进损伤修复和分泌细胞外信号分子等多种功能?其中,吞噬功能在神经发育?脑组织维持?突触重塑?神经退行性疾病发生发展及淀粉样β 蛋白的清除等方面都发挥着重要作用?本文就小胶质细胞在神经发育及神经退行性疾病中的吞噬功能及其调节机制作一简要综述,以期为神经退行性疾病的治疗提供新思路?

    Abstract:

    Microglia, a type of neuroglia, has a variety of functions such as phagocytosis, clearance, antigen presentation, promotion of repairment of injury and secretion of extracellular signaling molecules, in which phagocytosis of microglia plays a crucial role in maintaining brain tissue, remodeling synapses, clearance of several aberrant proteins such as amyloid β in neurodegenerative diseases, and in neurodevelopment. This review briefly summarizes the phagocytic function of microglia with underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases, aiming to provide a new thought for the therapy of neurodegenerative diseases.

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引用本文

李晶文,张丽,张连峰.小胶质细胞在神经发育和神经退行性疾病中的吞噬作用与调节机制[J].中国比较医学杂志,2018,28(4):120~126.

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历史
  • 收稿日期:2017-07-27
  • 在线发布日期: 2018-05-22
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