树鼩应用于病毒感染性疾病动物模型的研究进展
作者:
作者单位:

(1. 昆明理工大学医学院,昆明 650500; 2. 云南省第一人民医院昆明理工大学附属医院,昆明 650000; 3. 呼吸疾病国家重点实验室/ 呼吸疾病国家临床研究中心/ 广州医科大学附属第一医院,广州 510120; 4. 昆明医科大学,昆明 650500)

中图分类号:

R-33

基金项目:

国家自然科学基金资助项目(81760379,81471937);广州市属高校科研项目(1201410111);广州市属高校“羊城学者”科研项目(1201561571)


Research advances of application of tree shrew as an animal model of viral infectious diseases
Author:
Affiliation:

(1. Medical Faculty of Kunming University of Science and Technology, Kunming 650500, China; 2. The First People’s Hospital of Yunnan Province & Affiliated Hospital of Kunming University of Science and Technology, Kunming 650000; 3. State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120; 4. Kunming Medical University, Kunming 650500)

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • | |
  • 文章评论
    摘要:

    病毒感染是我国传染病致死的主要病因?建立一种能有效模拟人类感染病毒的动物模型,对病毒感染性疾病的致病机制和防治研究具有重要意义?树鼩作为灵长类动物的近亲,是近年建立和发展起来的新型动物模型,在病毒感染性疾病模型研究中突显优势和潜能?本文从树鼩的分类学?生理学和免疫学等生物学特征方面阐述了其应用于病毒感染性疾病动物模型研究的优势,并对树鼩在肝炎病毒?单纯疱疹病毒?流感病毒?肠道病毒等多种人类病毒感染性疾病模型应用中的最新研究进展予以比较和概述?

    Abstract:

    Viral infection is the main death cause of infectious diseases in China. The establishment of an animal model to mimic the progression of viral infectious diseases in humans is of great significance to the study of pathogenesis and prevention of viral infectious diseases. As a new animal model established and developed in recent years, tree shrew has showed obvious advantages and potentials compared with other non?human primates and mice which are commonly used as virus?infected animal models. In this paper, the biological advantages of tree shrew as a novel animal model of viral infectious diseases are summarized, including taxonomy, physiology and immunology. In addition, the latest application of tree shrew in the research of many viral infectious diseases such as hepatitis virus, herpes simplex virus, influenza virus and enterovirus infections are compared and summarized.

    参考文献
    相似文献
    引证文献
引用本文

周风梅,李润峰,袁兵,杨子峰,张荣平,张云辉.树鼩应用于病毒感染性疾病动物模型的研究进展[J].中国比较医学杂志,2018,28(6):115~120.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2018-01-05
  • 在线发布日期: 2018-07-20
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭