HIV 潜伏库治疗策略研究
作者:
  • 童玲

    童玲

    北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家卫生和计划生育委员会人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,新发再发传染病动物模型研究北京市重点实验室,北京 100021
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  • 薛婧

    薛婧

    北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家卫生和计划生育委员会人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,新发再发传染病动物模型研究北京市重点实验室,北京 100021
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  • 魏强

    魏强

    北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家卫生和计划生育委员会人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,新发再发传染病动物模型研究北京市重点实验室,北京 100021
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作者单位:

(北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家卫生和计划生育委员会人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,新发再发传染病动物模型研究北京市重点实验室,北京 100021)

中图分类号:

R-33

基金项目:

中国医学科学院医学与健康科技创新工程重大协同创新项目(2017?I2M?1?014); 十三五科技部传染病重大专项 (2017ZX10304402)


Research on the strategy of eradication of HIV latent reservoirs
Author:
  • TONG Ling

    TONG Ling

    Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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  • XUE Jing

    XUE Jing

    Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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  • WEI Qiang

    WEI Qiang

    Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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Affiliation:

(Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China)

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    摘要:

    HIV 潜伏库是指在免疫反应和抗病毒治疗压力下,HIV 潜伏的细胞和组织?尽管高效抗逆转录病毒疗法(HAART)的出现,有效地控制了HIV 感染,使得血浆中的病毒载量抑制在低水平或检测线以下,但是却不能彻底清除潜伏库中的病毒,一旦停止抗病毒治疗,即发生病毒反弹?因此,清除潜伏于宿主体内的HIV 是根治艾滋病的重大挑战?本文将对近年来艾滋病潜伏库的治疗策略做一综述?

    Abstract:

    HIV latent reservoirs are the latent cells and tissues of HIV under the pressure of immune responses and antiviral therapy. Although HIV infection is effectively controlled by the advent of highly active antiretroviral therapy (HAART) and the viral load in the plasma is suppressed to a low level which are undetectable by most clinical measures, HAART is not able to completely eradicate the virus in the reservoirs. The viral rebound occurs when antiviral therapy is ceased. Therefore, the eradication of HIV reservoirs is a major challenge for the therapy of AIDS. In this paper, we will focus on the strategies of eradication of AIDS latent reservoirs.

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引用本文

童玲,薛婧,魏强. HIV 潜伏库治疗策略研究[J].中国比较医学杂志,2018,28(6):121~126.

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历史
  • 收稿日期:2017-11-15
  • 在线发布日期: 2018-07-20
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