正常巴马小型猪与高血糖家系F 5 代血液生理生化指标比较研究
作者:
作者单位:

(1. 南方医科大学实验动物中心,广州 510515; 2. 广东医科大学, 东莞 523808; 3. 东莞松山湖明珠实验动物科技有限公司, 东莞 523808)

中图分类号:

R-33


Comparison of blood physiological and biochemical indexes between normal Bama minipigs and an F5 generation with hyperglycemia
Author:
Affiliation:

(1. Laboratory Animal Center, Southern Medical University, Guangzhou 510515,China; 2. Guangdong Medical University, Dongguan 523808; 3. Pearl Laboratory Animal Science and Technology Ltd, Dongguan 523808)

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    摘要:

    目的 对正常巴马小型猪和高血糖家系F5 代个体的血液生理生化指标进行比较和分析?方法 检测正常巴马小型猪和高血糖家系F5 代个体的空腹血糖?餐后2 h 血糖?胰岛素?胰高血糖素?糖化血红蛋白?胰岛素抵抗指数?血液生理指标和血液生化指标,并进行静脉葡萄糖耐量试验?结果 高血糖家系组的空腹血糖?餐后2 h 血糖?糖化血红蛋白和胰岛素抵抗指数比正常组的显著升高( P < 0. 05);静脉葡萄糖耐量试验显示,高血糖家系组的空腹血糖?30 min 血糖水平?120 min 血糖水平比正常组的显著升高( P < 0. 05);在血液生理生化检测中,高血糖家系组的胆固醇和低密度脂蛋白胆固醇比正常组的显著升高( P < 0. 05),而其余指标差异不显著?结论 巴马小型猪高血糖家系的F 5 代个体表现出高血糖水平和脂类代谢异常?

    Abstract:

    Objective To compare and analyze the blood physiological and biochemical indexes of normal Bama minipigs and the F5 generation of a minipig family with hyperglycemia. Methods The fasting blood glucose, postprandial 2 h blood glucose, insulin, glucagon, glycosylated hemoglobin, insulin resistance index, blood physiological index, and blood biochemical index were measured in normal Bama minipigs and the F5 generation of a hyperglycemic family; the intravenous glucose tolerance test was also performed. Results The fasting blood glucose, postprandial 2 h blood glucose, glycated hemoglobin, and insulin resistance index in the hyperglycemic group were significantly higher than those in the normal group ( P < 0. 05). The intravenous glucose tolerance test showed that the fasting blood glucose, 30 min blood glucose level, and 120 min blood glucose level in the hyperglycemic group were significantly higher than those in the normal group ( P < 0. 05). In the blood physiological and biochemical tests, the cholesterol and low?density lipoprotein cholesterol levels in the hyperglycemic group were significantly higher than those in the normal group ( P < 0. 05), but the differences of the other indexes were not pronounced. Conclusions The F5 generation of Bama minipigs showed hyperglycemia and abnormal lipid metabolism.

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邓俊成,苏小华,吕明,王超,顾为望.正常巴马小型猪与高血糖家系F 5 代血液生理生化指标比较研究[J].中国比较医学杂志,2018,28(10):36~41.

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  • 收稿日期:2018-04-25
  • 在线发布日期: 2018-11-15
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