Objective The possibility of using non addictive analgesics in a pharmacological teaching experiment was explored in order to continue the traditional analgesic experiment. Methods One hundred ICR mice were randomly divided into five groups: saline control group, meloxicam (5 mg/ kg) group, aspirin (0. 6 g/ kg) group, antodine (1. 2mL/ kg) group, and pethidine (5 mg/ kg) group. Mouse pain models were established using hot plate and acetic acid torsional method . Each group was administered their respective substances by intraperitoneal injection. The analgesic effects were observed for the non addictive analgesics compared with those in the control group and the addictive analgesic group. Results The result showed that the analgesic effects of meloxicam, aspirin, antodine, and pethidine were significantly higher than in the control group, when tested with the acetic acid torsional method ( P < 0. 001); those in the aspirin, antodine, and pethidine groups were superior to that in the meloxicam group ( P < 0. 01); and that in the antodine group was superior to those in the aspirin and pethidine groups ( P < 0. 05). Moreover, when tested with the hot plate method , the analgesic effects of aspirin, antodine, and pethidine were significant compared with that in the control group ( P < 0. 05, P < 0. 01), while those in the antodine and pethidine groups were better than for aspirin ( P <0. 01). Conclusions As nonaddictive analgesics, meloxicam, aspirin, and antodine can take the place of addictive analgesics in teaching experiments.