Objective To investigate the mechanism of aspirin on high salt-induced hypertension in Dahl saltsensitive rats. Methods Two-month-old Dahl salt-sensitive rats (Dahl SS) and salt-resistant rats (SS-13BN) were fed with Low salt (0. 12% NaCl, LS), High salt (8% NaCl, HS), High salt + Aspirin (8% NaCl +10 mg/ (kg·d)aspirin),or HS+ASA for 8 weeks. Blood pressure was measured by the tail cuff method. The expressions of renal inflammatory cytokines (IL-6, IL-1β, TNF-α) and eNOS and vWF in arteries were measured by real-time PCR and western blot,respectively. The number of skin M2 macrophages was measured by immunofluorescence. Results Blood pressure,expressions of renal IL-6, IL-1β, TNF-α, and arterial vWF were markedly increased, and the number of M2 macrophages in the skin, and eNOS expression in the arteries were significantly decreased in the high salt group compared with the low salt group. Aspirin inhibited all these events in rats on a high salt diet. However, the influence of high salt and aspirin was not observed in SS-13BN rats. Conclusions Aspirin attenuated salt-sensitive hypertension and arterial injury induced by a high salt diet in Dahl salt-sensitive rats via inhibiting platelet activated inflammation.