To select the appropriate mouse model of liver injury is of great significance for the research on prevention and treatment of liver disease, the study of its pathogenesis and the screening of drugs to protect the liver.According to references published internationally, mouse models of liver injury were classified into chemical,pharmacological, immunological, alcoholic, and partial hepatectomy studies. Based on the classification of models of liver injury in mice, the pathogenesis, dosage of drugs, time of model formation, applicable scope, and advantages and disadvantages were reviewed to provide a reference for the selection of experimental mouse liver injury models.