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首页 > 过刊浏览>2019年第29卷第2期 >106-110. DOI:10.3969/j. issn. 1671 -7856. 2019. 02. 018
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脂肪干细胞向神经方向诱导分化的研究现状
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(中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,北京 100021)

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R-33


Current status of the research on induced neural differentiation of adipose-derived stem cells
Author:
  • LI Keya

    LI Keya

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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  • BAI Lin

    BAI Lin

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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  • GAO Shuping

    GAO Shuping

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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  • QIN Chuan

    QIN Chuan

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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Affiliation:

(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China)

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    摘要:

    神经退行性疾病是一类以神经元退行性病变为主要特征的疾病,目前在全球范围内频发,尚无有效的治疗措施?干细胞具有自我更新和定向分化的潜能,为神经退行性疾病中大脑功能的恢复提供了新的治疗方法?脂肪干细胞是由中胚层发育而来的多潜能干细胞,在特定的生长因子和环境诱导下可以向不同的谱系分化,同时具有获取方便?容易培养的特点,因此脂肪组织来源的干细胞在治疗神经退行性疾病方面有其独特优势?本文就神经退行性疾病概况?脂肪干细胞生物学特性及向神经方向诱导分化的研究现状以综述?

    Abstract:

    Neurodegenerative diseases are common conditions globally that involve the degeneration of neurons, for which no effective curative measures are available. Stem cells have the potential to undergo self-renewal and directional differentiation, potentially providing new therapeutic method for the recovery of brain function in neurodegenerative diseases. In recent years, with the development of stem cell biology, it has been found that adipose stem cells are pluripotent stem cells that develop from the middle germ layer, which can differentiate into different lineages upon exposure to specific growth factors and environmental conditions.They have the benefits of being easily accessible to researchers and simple to culture. Therefore, adipose tissue-derived stem cells have unique advantages in treating neurodegenerative diseases. This article provides an overview of neurodegenerative diseases, the biological characteristics of adipose-derived stem cells, and the conditions for differentiating them into the components of neural systems.

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引用本文

李珂雅,白琳,高舒平,秦川.脂肪干细胞向神经方向诱导分化的研究现状[J].中国比较医学杂志,2019,29(2):106~110.

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  • 收稿日期:2018-07-29
  • 在线发布日期: 2019-03-14
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