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首页 > 过刊浏览>2019年第29卷第5期 >58-62. DOI:10.3969/j. issn. 1671 -7856. 2019. 05. 009
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食蟹猴血糖值与季节性气温变化的关系
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(广东省生物资源应用研究所/ 广东省动物保护与资源利用重点实验室/广东省野生动物保护与利用公共实验室,广州 510260)

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R-33


Association of plasma glucose in cynomolgus monkeys with seasonal temperature variation
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(Guangdong Institute of Applied Biological Resources; Guangdong Key Laboratory of Animal Conservation and Resource Utilization; Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangzhou 510260, China)

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    摘要:

    目的 检测并分析食蟹猴血糖值一年内季节性变化,考察食蟹猴血糖值在不同季节间是否存在显著差异?同时比较便携式血糖仪与全自动生化分析仪测定值之间差异?方法 采集食蟹猴静脉血,利用全自动生化仪及便携式血糖仪检测不同季节食蟹猴血糖值,进行比较分析?结果 显示食蟹猴血糖值呈现夏季最低,冬季最高,春秋位于两者间的周期性波动?且夏→秋和冬→春时间段血糖变化幅度(每℃约0. 20 mmol/ L)大于秋→冬和春→夏的变化幅度(每℃约0. 06 mmol/ L)?便携式血糖仪与自动生化分析仪之间血糖值差异符合国家标准,通过比较分析便携式血糖仪可以应用于食蟹猴血糖值检测?结论 本研究填补食蟹猴血糖相关研究中,季节性温度变化对其影响分析,有利于在以后动物实验中,充分考虑两者的相关性来对数据进行合理分析?

    Abstract:

    Objective To examine whether the fasting plasma glucose (FPG) of cynomolgus monkeys (Macacafascicularis) is significantly different between different seasons. The aim of this study was to investigate the correlationbetween FPG and seasonal temperature variation in a year, and to compare the FPG measured by a portable blood glucosemeter with that measured by an automatic biochemical analyzer. Methods Venous blood of monkeys was collected, andblood glucose values of monkeys in different seasons were measured by an automatic biochemical analyzer and portableblood glucose meter. Results FPG levels in cynomolgus monkeys peaked in the winter, reached the lowest level in thesummer, and fluctuated within this range during spring and autumn. Changes in FPG levels during the periods winter→spring and summer→autumn were higher than the periods autumn→winter and spring→summer, with the amplitudechanges of approximately 0. 20 mmol/ L per℃ and 0. 06 mmol/ L per℃, respectively. The differences between FPGmeasured by portable blood glucose meter and automatic biochemical analyzer were in accordance with national standards,indicating that the portable blood glucose meter can be used to detect FPG in cynomolgus monkeys. Conclusions Theresults of this study demonstrate the association of FPG with seasonal temperature variation in cynomolgus monkeys and provide a reasonable analysis of the data in future animal experiments.

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孙云霄,张艳春,饶军华,季芳,靳丽莎,刘晓明,张礼标.食蟹猴血糖值与季节性气温变化的关系[J].中国比较医学杂志,2019,29(5):58~62.

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  • 收稿日期:2018-11-12
  • 在线发布日期: 2019-06-05
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