An increase in the global population and climate warming over the past few decades has increased theglobal epidemic and incidence of Dengue fever, which is now a global public health problem. It is essential to establishideal animal models of Dengue fever to study the infection mechanism and pathogenesis of Dengue virus. In view of thespecies specificity and specific pathogenesis of Dengue virus, research on animal models of Dengue virus infection facesmany challenges. Specifically, immunodeficient mice infected with Dengue virus produce high levels of viral replication andsevere disease manifestations, such as increased vascular permeability and thrombocytopenia; however, some symptomssuch as neurological symptoms differ from those of humans. The humanized mouse model of Dengue virus infection can studythe human immune response to Dengue virus, but it is not comprehensive or accurate. Dengue virus also effectively infectsnon-human primates, although they do not usually develop significant clinical symptoms. Therefore, it is necessary toimprove and establish Dengue virus infection models to support research on the pathogenesis of Dengue virus and thepreclinical evaluation of antiviral drugs and vaccines. This paper brings together the research progress of animal models ofDengue virus infection in recent years, and provides reference information for the research and application of the Dengue virus infection model.